P.A. MURARO, A. LUGARESI, D. GAMBI some of the pathological facets of a number of sclerosis (MS) lesions were recognized for over a century. it's only lately, besides the fact that, that diverse styles of demyelination were associated with distinctive pathways of immune-mediated tissue destruction. particularly, the inter-individual heterogeneity of MS lesions has steered that diverse mechanisms might act in several sufferers, accounting for the range saw in medical path, immunological findings in peripheral blood and cere­ brospinal fluid (CSF), and reaction to immunomodulatory remedies. to supply an summary of the elemental mechanisms probably desirous about MS lesion initiation and improvement, a global assembly used to be geared up within the context of the yearly Congress of the Italian Neuroimmunology organization (AINI), held on the collage of Chieti, in Chieti Italy on 29 October 1998. The excessive common of displays brought on us to file them in prolonged shape, to focus on contemporary seasoned­ gress within the realizing of simple mechanisms maintaining MS immuno­ pathogenesis. A important position within the attainable mechanisms resulting in myelin destruc­ tion has been attributed to T lymphocytes reactive to myelin antigens. stories at the myelin antigen-specific T cellphone repertoire have contributed major advances to our wisdom of autoimmunity (Chapters 1,2).